AIM Honor (Ningbo) Biopharmaceutical Co., Ltd., as a professional rabies vaccine manufacturer, offers Vaccine for Rabies After Bite, a specialized emergency immunization product for Category II/III exposures after dog bites. It covers two main categories: conventional Vero cell rabies vaccine and the next-generation serum-free Vero cell rabies vaccine.
AIM Honor is a supplier of Vaccine for Rabies After Bite from China. This product comes in two types: conventional
Vero cell rabies vaccine and the next-generation serum-free Vero cell rabies vaccine. The former uses mature
technology and has a stable supply, while the latter avoids risks associated with bovine serum through a completely
serum-free culture process.
Both products achieve a 100% antibody seroconversion rate within 14 days and are administered via intramuscular
injection, suitable for emergency prevention and control needs in various dog bite exposure scenarios. It is a core
solution for post-exposure rabies prevention!
What is the Vaccine for Rabies After Bite?
This vaccine is a specialized preparation for emergency prevention after exposure to dog bites. The standard version
has the national drug approval number S20073014 and has been supplied to over 2,000 disease control institutions in
China for a long time. The serum-free version is an innovative upgraded product, which has completed Phase III
clinical trials and its marketing application has been accepted by the CDE (China Center for Drug Evaluation). Its
core advantage lies in its completely serum-free culture process – from Vero cell resuscitation and expansion to
virus culture, no bovine serum is added throughout the entire process, completely eliminating the risks of
batch-to-batch quality fluctuations, viral contamination, and allergic reactions caused by bovine serum. This
process complies with WHO guidelines on avoiding the use of bovine-derived raw materials in biological products.
For graded prevention and control needs after dog bite exposure, Class II exposure (non-bleeding bites/scratches)
can be vaccinated directly according to a 5-dose schedule on days 0, 3, 7, 14, and 28; Class III exposure (bleeding
bites, mucous membrane contact) requires combined use with rabies immunoglobulin (20 IU/kg).
100% seroconversion is achieved 14 days after vaccination, and the neutralizing antibody GMC value far exceeds the
WHO protection threshold of 0.5 IU/ml, with immunity lasting for more than 3 months, building a strong immune
barrier for people exposed to dog bites.
Product Specification
Item
Conventional Vero cell rabies vaccine
Serum-free Vero cell rabies vaccine
Core strain
Local aG fixed toxin
Innovative PV-2061 fixed toxin (99.62% homology to G protein)
Key processes
Standard Vero cell culture, preservative-free.
High-density culture of Vero cells without serum throughout the entire process, resulting in no bovine
serum residue.
Immunization schedule
Only a 5-dose intramuscular injection regimen is supported.
Supports both the 5-dose regimen and the WHO simplified 4-dose regimen.
Antibody GMC (14 days)
Approximately 6.0 IU/dose
32.76 IU/mL (significantly higher than the standard version)
Characteristics of adverse reactions
The main symptom was localized pain (22.4% of cases were classified as Grade 1).
The reactions were mostly mild, with no serious adverse reactions of grade 3 or higher.
Applicable scenarios
Routine emergency vaccinations at primary healthcare facilities.
Vaccination in high-end medical settings and for individuals at high risk of allergic reactions.
Core Advantages
The conventional version has high cost-effectiveness and large supply, meeting the mass emergency vaccination needs
of primary medical institutions; the serum-free version has advanced technology, adapting to high-end scenarios such
as top three hospitals and foreign-related medical institutions, as well as allergic populations, filling the gap in
the domestic serum-free rabies vaccine market.
Both products can achieve 100% antibody seroconversion within 14 days; the serum-free version also supports the WHO
simplified 4-dose schedule, reducing the number of vaccinations while ensuring immune effect and improving the
vaccination compliance of exposed populations.
The conventional version complies with the 2020 edition of the Pharmacopoeia of the People's Republic of China
Volume III, with a 100% batch release qualification rate for 17 years; the clinical data of the serum-free version
has been accepted by CDE, and the process complies with international biopharmaceutical raw material usage
standards.
Application Scenarios
Emergency medical scenarios: Used for emergency vaccination within 24 hours after dog bites in emergency centers and
trauma hospitals to quickly initiate immune protection.
Primary prevention and control network: Community health service centers and township health centers provide regular
vaccination services for dog bite populations in rural and suburban areas.
Special population vaccination: The serum-free version can be used for children, the elderly and allergic dog bite
populations to reduce vaccination risks.
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