Advanced Hepatitis A Vaccine Factory Direct

AIM Vaccine is a professional Hepatitis A Inactivated Vaccine Diploid Cell manufacturer and supplier in China, we apply advanced technology; during the years, we continuously expand our pipeline of products, as we have strong production and innovation abilities.

What is Hepatitis A vaccine?

The hepatitis A vaccine is an inactivated viral vaccine that stimulates the body to produce protective antibodies against the hepatitis A virus (HAV), preventing infection and the development of hepatitis A.

It is typically administered as a 2-dose series (initial dose + a booster 6–12 months later) for long-term immunity, and is recommended for children, travelers to high-risk regions, and individuals with increased exposure risk to HAV.

Why do we need vaccines specifically for hepatitis A?

Hepatitis A vaccines are essential because the hepatitis A virus (HAV) causes acute liver infection with potentially severe symptoms (jaundice, liver damage, even fulminant hepatitis in high-risk groups), and it spreads easily via fecal-oral route (contaminated food/water, close contact) with no specific cure for the infection.

Vaccination is the most effective way to build long-term active immunity against HAV, preventing infection, stopping the virus from spreading in communities, and eliminating the risk of life-threatening liver complications—especially for children, the elderly, and people with pre-existing liver disease who are more vulnerable to severe HAV outcomes.

What’s differences between Inactivated hepatitis A vaccine and Live attenuated hepatitis A vaccine?

Elaborate on the advantages of the hepatitis A vaccine produced by AIM Action

The human diploid hepatitis A vaccine produced by AIM Action Biopharmaceutical Co., Ltd. — the inactivated hepatitis A vaccine (human diploid cells) — uses the internationally recognized safe human diploid cells (KMB17) as the culture medium, eliminating the potential viral contamination and tumorigenic risks associated with animal-derived cells. It represents an advanced and next-generation vaccine production technology that is purer and safer.

Core Features: Human-derived Cell-based Safety Assurance

1. Purity, Eliminating Animal Origin Risks: Manufactured from human diploid cells, this vaccine completely avoids potential unknown pathogens or xenogeneic proteins introduced by animal cells such as chicken embryos or hamster kidneys, ensuring purity from the source.

2. Safety record excellence: Human diploid cell matrix has been safely used worldwide for decades, widely used in high-end vaccines such as rabies, chickenpox, etc., and its safety has been clinically validated over a long period of time.

3. The immune response is more natural: The virus is cultured in human cells, and its antigen structure is closer to the shape recognized by the body during natural infection, which may induce a more balanced and lasting immune protection.

4. Wider applicability: With its high safety profile, it provides a vaccination option for a wider range of people, including those with immunocompromised status, without the concern of animal-derived allergies.

AIM Action’s hepatitis A inactivated vaccine, was listed on June 1, 2003, is one of the first inactivated vaccine manufacture to occupy the market in China.

After more than 20 years, AIM Action HAV has been tested and made a positive contribution to the elimination of viral hepatitis in China.

This vaccine offers precise dosing for both adults (over 15 years old) and children (1-15 years old including 15 years old). After completing two full doses, it induces long-term or even lifelong protective antibodies, effectively blocking viral transmission.

Hepatitis A Vaccine for Children

Engineered for children's delicate constitution and rapidly developing immune systems, the inactivated hepatitis A vaccine (human diploid cell) produced by AIM Action Biopharmaceutical Co., Ltd.（The wholly-owned subsidiary of AIM Vaccine Co., Ltd.）delivers a 0.5ml pediatric-specific dose (containing 320EU of hepatitis A virus antigen), achieving optimal balance between safety and immune efficacy. Utilizing internationally certified human diploid cell culture and inactivation technology, it provides long-lasting protection for children of 1-15 years old (including 15 years old).

[Drug Name]

Generic name: Hepatitis A Vaccine (Human Diploid Cell), Inactivated

[Components and Description]

The inactivated hepatitis A vaccine is a preparation made from hepatitis A virus (HAV) LV8 strain grown in human diploid cell KMB17 strain. After cultivation and harvest, the virus suspension Is purified and inactivated. A quantity of aluminum adjuvant is added to make the vaccine. It is a slightly milky-white suspension. Stratified precipitate may form which can be dispersed by shaking.

Active constituent: Inactivated hepatitis A virus.

Excipients: Aluminum hydroxide, 2-phenoxyethanol, glycine,sodium hydrogen sulfite, sodium hydroxide, and phosphate buffered saline (PBS).

[Eligibles]

Hepatitis A-susceptible individuals aged 1-15 years old (including 15 years old).

[Action and Use]

The product can induce immunity against hepatitis A virus in recipients following immunization. It is used to prevent hepatitis A.

[Strength]

0.5ml per vial or syringe, 0.5ml per single human dose for children, containing 320EU of hepatitis A virus antigen.

[Administration and Dosage]

(1) Shake well before use. Inject single human dose im.at deltoid insertion area of the lateral upper arm.

(2) Eligibles of 1-15 years old (including 15 years old) should be administered the pediatric dose, A single dose of vaccine is used for primary immunization, and 1 dose of vaccine for booster immunization at 6 months interval. Each dose is 0.5 ml.

[Storage]

Store and ship the product at 2-8℃, protected from light.

[Packaging]

This product is packaged in a pre-filled syringe or vial , with 1 vial or syringe per small box.

[Validity Period]

36 months.

Hepatitis A Vaccine for Adult

The AIM Action Adult Hepatitis A Vaccine is a preventive product specifically optimized for the immune system characteristics of individuals over 15 years old. Unlike pediatric formulations, this product contains 640EU of hepatitis A virus antigen per 1.0ml. This clinically validated dosage effectively stimulates the adult body to produce sufficient and long-lasting protective antibodies. Adults face relatively higher exposure risks due to work stress, frequent social interactions, and increased travel. With a focus on "strong protection and convenient administration," the vaccine provides a reliable "liver insurance" through a two-dose regimen (0 and 6 months), seamlessly integrating health protection into modern life.

[Drug Name]

Generic name: Hepatitis A Vaccine (Human Diploid Cell), Inactivated

[Components and Description]

The inactivated hepatitis A vaccine is a preparation made from hepatitis A virus (HAV) LV8 strain grown in human diploid cell KMB17 strain. After cultivation and harvest, the virus suspension Is purified and inactivated. A quantity of aluminum adjuvant is added to make the vaccine.It is a slightly milky-white suspension. Stratified precipitate may form which can be dispersed by shaking.

Active constituent: Inactivated hepatitis A virus.

Excipients: Aluminum hydroxide,2-phenoxyethanol, glycine,sodium hydrogen sulfite, sodium hydroxide, and phosphate buffered saline(PBS).

[Eligibles]

Hepatitis A-susceptible individuals aged over 15 years old (excluding 15 years old).

[Strength]

1.0 ml per syringe, 1.0 ml per single human dose for adult, containing 640 EU of hepatitis A virus antigen.

[Administration and Dosage]

(1) Shake well before use. Inject single human dose IM at the deltoid insertion area of the lateral upper arm.

(2) Eligibles over 15 years old (excluding 15 years old) should be given the adult dose, with 1 dose of vaccine for initial immunization and 1 dose of vaccine for booster immunization at 6-month intervals. Each dose is 1.0 ml.