ACYW135 Meningococcal Polysaccharide Vaccine

AIM Persistence -  Xin'er Cong®

The ACYW135 meningococcal polysaccharide vaccine is provided by the China manufacturer AIM Persistence. It is administered once to children over 2 years old and adults, with each dose being 0.5ml. Vaccination should be completed before the meningococcal meningitis epidemic season.

Vaccination Target

At present, it is only recommended for use in high-risk populations of children over 2 years old and adults in the following scope:

1. Those who travel to or live in high-risk areas, such as the African meningitis belt (epidemic areas of Group A, C, Y, and W135 Neisseria meningitidis).

2. Those who may come into contact with Group A, C, Y, and W135 Neisseria meningitidis from the air in laboratory or vaccine production work.

3. High-risk populations in areas where the national health administrative departments predict an outbreak of Group Y and W135 Neisseria meningitidis infection based on epidemiological investigations.

Instructions for Use

1. Open the vaccine vial and add the indicated amount of diluent for reconstitution, shake well, and use immediately.

2. Administer the product by subcutaneous injection at the attachment site of the deltoid muscle on the outer side of the upper arm.

3. Dosage: Children over 2 years old and adults are vaccinated once, and each human dose is 0.5ml. Vaccination should be completed before the epidemic season of cerebrospinal meningitis.

4. Booster immunization (recommended abroad): High-risk individuals in epidemic areas, especially children under 4 years old for the first vaccination, should consider revaccination 2 to 3 years after the initial immunization if they continue to be at high risk. Although it has not been determined whether revaccination is necessary for older children and adults, revaccination should be considered within 3 to 5 years after the initial immunization if the antibody level drops rapidly 2 to 3 years after vaccination.

There is no study data on the duration of immunity and booster immunization for this product.

Contraindications

Do not use this product in the following cases:

1. Those who are known to be allergic to any ingredients of this product.

2. Those with epilepsy, convulsions, brain diseases, and a history of allergies.

3. Patients with kidney disease, heart disease, active tuberculosis, HIV infected, and other acute diseases.

Individuals with severe chronic diseases, or are experiencing the acute exacerbation of chronic diseases.

4. During any acute infection or febrile illness.

5. This product has not been tested for reproductive toxicity in pregnant women and experimental animals, and it is unknown whether it will affect the fetus. Therefore, pregnant women should not be vaccinated for this vaccine, especially in the first three months of pregnancy.

Clinical Trials and Data

A clinical trial involving 900 people showed that the antibody seroconversion rates of four serological tests A, C, W135, and Y of Meningococcal polysaccharide were all greater than 96% one month after vaccination, indicating good immunogenicity.

Xin’er Cong® ACYW135 meningococcal polysaccharide vaccine has a shelf life of up to 36 months. (High water content in freeze-dried formulations can affect the shelf life and stability.)

Professionally Operated and Standardized Workshop

Professional and modern production workshops are the cornerstone of high-quality products!

Production Details

● Implement stricter internal control standards for bacterial endotoxin residues, resulting in lower residues and better safety.

● It contains no preservatives and is safer for preventive use.

● 100KD imported membrane cell ultrafiltration process, with high antigen purity;

● The preparation part is fully controlled in A B+A grade environment throughout the process, with high cleanliness and safer products.

● Safety observation: The incidence of adverse reactions such as fever, local redness, swelling and pain is extremely low.