Freeze Dried Rabies Vaccine Vero Cell Injection

Globally recognized biopharma supplier AIM Honor (Ningbo) Biopharmaceutical Co., Ltd. delivers Freeze Dried Rabies Vaccine Vero Cell Injection for international public health procurement. This lyophilized injectable vaccine adopts optimized Vero cell culture technology, capable of triggering complete antibody seroconversion within 14 days after standardized immunization. The formula excludes preservatives and antibiotics, minimizing impurity residues to achieve balanced safety and immune efficacy. Supported by independent aGV virus strain research and mature injection formulation technology, we provide flexible bulk order solutions and stable long-term cross-border supply for global distributors and medical institutions.

International buyers can source Freeze Dried Rabies Vaccine Vero Cell Injection directly from our factory. This lyophilized injectable preparation supports both preventive pre-exposure immunization and emergency post-exposure prophylaxis for all age groups and complies with global intramuscular vaccination norms. It is widely adopted in national rabies elimination programmes across multiple regions. Reach out to our commercial team to get detailed quotation and technical documents.

Vaccine Formula & Physical Traits

Freeze Dried Rabies Vaccine Vero Cell Injection is manufactured based on rabies fixed aGV virus cultivated on Vero cell substrates. After cell incubation and virus harvesting, viral suspension undergoes inactivation, concentration and deep purification. Human albumin, sucrose and gelatin serve as stabilizers before lyophilization treatment. Visually, the finished product appears as a white loose cake; after mixing with matched solvent, it turns into transparent homogeneous liquid. No preservative ingredients are added during the whole production flow.

Active ingredient: Inactivated rabies fixed virus

Excipients: 1% human albumin, 1% gelatin, 5% sucrose

Diluent: Sterile water for injection

Technical Specifications

● Volume after reconstitution: Each single vial yields 1.0ml vaccine. One vial is matched with 1.0ml sterile water for injection to complete one human immunization dose.

● Minimum potency threshold: Potency value of each vaccine dose shall not be lower than 2.5IU.

Suitable Immunization Groups

Immunization with this vaccine stimulates human bodies to generate specific protective antibodies against rabies virus so as to prevent rabies infection. Two major crowds are targeted for vaccination scenarios.

● Post-exposure population: People of all ages bitten or scratched by suspected rabid animals. Immediately flush wounds with clean water or soap water, disinfect wound surface with iodine tincture or ethanol, and launch vaccination according to post-exposure immunization schedule as quickly as possible.

● Pre-exposure high-risk personnel: Professionals constantly exposed to rabies infection risks, including veterinarians, animal breeders, forest workers, slaughterhouse staff and rabies laboratory operators, who need routine preventive vaccination.

Vaccination Procedures & Dosage Rules

Mix freeze-dried vaccine powder with matched sterile water for injection as specified and shake thoroughly before administration. Freeze Dried Rabies Vaccine Vero Cell Injection is delivered by intramuscular injection on upper arm deltoid muscle. For infants and toddlers, the injection site is selected on the anterolateral thigh muscle.

For post-exposure immunization, the standard programme consists of five separate injections carried out on day 0, day 3, day 7, day 14 and day 28. Children follow identical dosage standards. Under certain special circumstances, the first vaccine dose needs to be doubled. Such circumstances cover recipients who received rabies immunoglobulin or rabies antiserum one day or longer prior to vaccination, patients suffering from congenital or acquired immunodeficiency, recipients under immunosuppressive therapy including antimalarial medications, elderly groups, and those starting vaccination 48 hours or later after animal exposure incidents.

Clinical disposal schemes differ according to exposure grading standards.

Category I Exposure

Simple animal contact or intact skin licked by animals without any skin damage. No wound treatment or vaccination is required.

Category II Exposure

Animal bites or scratches that do not cause bleeding. Vaccination following standard post-exposure protocol is mandatory.

Category III Exposure

Bites or scratches leading to bleeding, mucous membrane contaminated by animal saliva or broken skin licked by suspected rabid animals. Vaccination combined with rabies antiserum (40IU/kg) or rabies immunoglobulin (20IU/kg) must be carried out immediately. Serum or immunoglobulin should be infiltrated around wound areas as much as possible, and remaining volume injected intramuscularly. These biological preparations can only be used once.

For pre-exposure preventive immunization, three doses will be implemented on day 0, day 7, day 21 or day 28.

Specialized booster vaccination guidance applies to people who have received immunization previously. Those who have completed full vaccination within one year only need two booster shots on day 0 and day 3 after new exposure. If the primary vaccination was finished over one year ago, individuals should complete the whole immunization programme again after exposure. People who have finished full vaccination plus booster doses within three years can take two booster doses on day 0 and day 3 upon new exposure. For recipients whose primary vaccination and booster injections were completed more than three years ago, a full immunization cycle needs to be implemented again after exposure.

Possible Immunization Reactions

Common adverse reactions

Within 24 hours after injection, injection site discomfort such as redness, swelling, ache and itch may occur. These symptoms can disappear naturally without special intervention.

Systemic symptoms may include mild fever, fatigue, headache, dizziness, joint soreness, myalgia, vomiting and stomach ache. Generally, these manifestations relieve spontaneously without targeted treatment.

Infrequent adverse reactions

Recipients with persistent moderate or high fever can adopt physical cooling or symptomatic treatment to avoid febrile convulsion risks.

Extremely rare adverse reactions:

Allergic rash: Urticaria mostly emerges within 72 hours after vaccination. Patients need timely anti-anaphylactic treatment.

Anaphylactic shock: It may occur within one hour after injection. Emergency rescue including adrenaline injection should be performed without delay.

Allergic purpura: Seek medical treatment rapidly and receive hormone anti-allergy therapy. Improper or delayed treatment may induce purpuric nephritis complications.

Patients developing angioneurotic edema or nervous system adverse reactions must accept timely medical management.

Vaccination Restrictions

Rabies disease carries a 100% fatality rate, hence no contraindications exist for post-exposure emergency vaccination.

Pre-exposure immunization contraindications:

● Persons with confirmed allergic response to any vaccine composition, including excipients and antibiotics

● Patients suffering from acute illness, severe chronic disease, acute attack of chronic disease or fever

● Patients with uncontrolled epilepsy or other progressive nervous system disorders

Storage Conditions & Expiry

● Storage and transportation requirement: Keep temperature stable between +2 °C and +8 °C, avoid light irradiation.

● Shelf life: 36 months under qualified storage environments.

GMP Compliant Manufacturing Workflow

The production of Freeze Dried Rabies Vaccine Vero Cell Injection strictly complies with international GMP standards inside the standardized clean workshops of AIM Honor. Multiple core technical steps guarantee consistent batch-to-batch vaccine quality.

High-efficiency purification process is adopted on production lines equipped with 20m² ultrafiltration equipment and 600mm chromatography system for multi-stage purification. Foreign protein, residual DNA and other impurities are effectively removed to ensure antigen purity meets global medical standards.

We operate a rigorous quality monitoring system, where internal control standards are stricter than official pharmacopoeia requirements. Key indicators including endotoxin ≤10EU/dose, sterility testing and precise pH monitoring maintain stable and uniform product quality among batches.

The facility is equipped with a 40m² freeze-drying unit to carry out standardized lyophilization craft, lowering residual moisture content, retaining antigen activity and extending valid period. All formulation operations are carried out in B+A grade clean environment to safeguard product safety.

Cell strain culture and subculture procedures are completed within closed aseptic operation systems under B+A cleanroom specifications. Production staff wear full closed protective gear. All strain passaging and cell expansion operations follow strict aseptic protocols to prevent external pollution.

High-precision culture equipment precisely regulates temperature, pH and other parameters to guarantee stable strain vitality and cell proliferation performance. This procedure serves as the core foundation to preserve antigen purity and activity, laying reliable prerequisites for subsequent purification and preparation processes.

Frequently Asked Questions

Q1: Can this vaccine be administered to children and pregnant women?

A1: For post-exposure prophylaxis, there is no age limitation. Children can receive vaccination with standard dosage. For pregnant women exposed to rabies risk, the benefits of vaccination outweigh potential risks, and vaccination is recommended. For pre-exposure vaccination of pregnant women, please evaluate comprehensively under professional medical guidance.

Q2: How long can the reconstituted vaccine be stored before injection?

A2: After mixing with sterile water for injection, the vaccine should be injected immediately. Long-term storage after reconstitution is prohibited to avoid activity decline and contamination risks.

Q3: Is temperature deviation allowed during international transportation?

A3: Continuous storage between 2~8°C is required. Short-time temperature fluctuation outside the range is not recommended. We can provide qualified cold chain transportation solutions for overseas orders.

Q4: Can I mix this vaccine with other vaccines in one injection?

A4: Simultaneous injection at the same site is forbidden. If other vaccines are needed, separate injection sites and appropriate time intervals are suggested following local vaccination guidelines.

Q5: What documents can your company provide for customs clearance and registration?

A5: We can supply COA, manufacturing license, GMP certification, packing list, commercial invoice and other required files. Contact our sales team to confirm documents matching your national registration requirements.

Q6: What is your minimum order quantity for bulk procurement?

A6: MOQ can be negotiated according to target country and delivery schedule. Please send an inquiry to obtain flexible pricing and delivery arrangements.